I have experimented with low timing low punch, low and high respectively, high and high, high and low. The best result is from low timing high punch.
I run Turnigy 2s 5000mah 40-50c
I've ran it on 4s 2p (4x batteries which should be more than enough grunt, I think it works out to be 400amp constant) & 6s 1p.(3x batteries)
I've turned off two ESC's and still have the same result from the 3rd.
My ESC's are Hobbyking 150 amp.

It seems from stories, my experience and a mates that high amp ESC's seem to cog.
I've previously had an Ezrun 35 or 60 amp (can't remember) speedy with a 5.5t setup on a 2s Lipo, geared very high and never had an issue.