It has nothing to do with expo or other settings. It's all about latency. Some radios (even high end ones) have very high latency and some have very low latency and it does make a difference. Not so much in terms of one being better than the other as what you are used to.

Now in offroad, it isn't as noticeable. Only the top pros would really notice the difference, but that difference is there. Go 1/12th mod or 1/8th onroad racing and get good enough to compete for a mains against good comp. Try some different radios then and you WILL see the difference.