Is the battery charged?? some lrp esc's come with them in lipo mode and if the batt is low it will whine but their isn't enough amps to make the motor go.

hook that lipo in your tc5 and see it works since you know that rx,esc,motor, system works.

you can also reset the model memory on your 4pk so it will at factory default settings. Also make sure that the sub-trim is at zero and the epa is at 100 high and low. Some esc's don't like the epa to be 120 high/low.