I will say this with reservation, Yes you can go there just watch the temp, it may get real fussy at low altitudes, so it depends on where your located. Also watch out for detonation. I would recommend a cold plug like an odonnel 99 or an MC9 mccoy. In the turbo situation try a 7 and if alls good drop to a 6.

what its going to do for you is add torque you may lose a few rpm on the top. The other way to skin the cat so to speak is to go to 40% and use the cold plugs at .018 this works well in moderate conditions. at low alt or above 80 degree conditions you may need to go .021. Air density,temp and pipe wave strength are the critical factors that will determing the point of detonation at a given trapped compression ratio. It is something you will need to fine tune for wherever you are in the world and the conditions of the moment

I've tried larger combustion chambers with tight head clearances but the squish velocity is just to slow in my opinion to achieve the burn rates in the cylinder I'm looking for.

I'm really big on chamber design,squish velocity, tumble and burn rates in the cylinder. Max power is all about cylinder charge speed, tumble and burn rate at the highest exhaust timing you can get away with without killing low speed torque. Thats the jist in a nutshell.

you'll notice that automotive manufacturers are dragging huge amounts of power out of older engine designs like the pushrod gen 4 small block engines. It has come from 4 things
1 injector targeting
2 port swirl
3 combustion chamber design
4 charge direction at the plug

yes their 4 strokers but those for me are the highest priorities on my list.

Timing IE. the camshaft/valves (crankshaft, port shape)is the easy part.

the oddity on 2 strokes is the tuned pipe, often over looked for the cheap or cool pipe of the week will make or break the performance of the engine.

It is the single most important part of the combination bar none. Throw all that stuff I mentioned above this line away and I can tell you for a fact that the proper pipe will wring out more power as a single item that all the above combined.