If you do end up with a 2S situation - setup a high-C 2S2P or 2S3P configuration to allow for higher amp draw. I have a Mamba/Neu 2650 and have run 2S1P to test it out a while back. It works - but you'd have to add 2-3 teeth to the pinion size over a 3S1P to be a viable speed.
Motors like the 2200 have a certain wattage rating - so to get to that wattage on a lower voltage battery - they need to pull amps - that's why doing something like a 2S2P setup with two 30C batteries may work ok.