They can all pretty much handle 2S 7.4v LiPos... few have a LiPo voltage cutoff... and thats the only problem. Some of the newer RTR speed controls have a cutoff.. but none of the older top of the line brushed ESCs have them.. I run LiPos still with my Novak GTX brushed stock motor 2wd.. no problems.. I just never run the battery that far down. If I practice, I only run about the same time as a race...
Jerome
