The two best and most comfortable radios on the market (not including the 4pk, never tried it) are the Ko ex10 Helios and the M11. Period. M8 is also very comfortable, but a bit dated--and you'd have to get a used one.
3pks is a very nice radio--incredible electronics, but it has kind of an uncomfortable trigger IMO and is very top heavy--even when using the stock 8-cell ni-cd or ni-mh. I never thought it was that comfortable while I was running it. I do think it has the best features and electronics though.
If the 4pk has the same weird trigger as the 3pk that is a strike against it. Otherwise it looks like it performs fantastic--but not having a module prevents me from running it with my Spektrum stuff. No way I am going to get 4 Futaba fAst receivers at $80-$90 (or whatever) a piece just to run the 4pk.
EX1 is a cool piece, looks retro and all, and I like the simple screen and controls--but its ergonomics are dated and it has awful steering feel. From the moment brought it home and tried it I knew in the back of my mind it WAS NOT the radio for me. Very, very uncomfortable for even avg. sized hands. If you have slightly larger hands or fat fingers you will not like running it. I never got used to it, in the 3 or 4 nights I ran it my lap times were CLEARLY off my usual pace.
Ex10 Helios suits me the best. Its nice and large for wide fingers, superb balance, not too heavy and great steering and throttle trigger. I would recommend it without hesitation over the 3pks, ex1, dx3r. Believe me, the ex10 is a FAR better radio than the ex1. I haven't found a single person who likes the ex1 better. The ex1 has that weird, super dated, plastic diamond dimples on the grip--stuff from the 80s--yuck!!
Go for the ex10 Helios or the M11, you won't regret it. If you already have Spektrum I would rule the 4pk out as you will have to switch all your receivers to Futaba FAST.