The Kyosho and Mugen handle and fly very similar. They are on par with each other in durability as well. Pick which one you think looks prettier, or which one has better parts availability where you race because there is very little functional difference.
The Losi IMO doesn't handle BETTER. It just handles a little different as others have said, more like a TC. It does fly better than the Kyosho and Mugen because of the centered engine layout. The con to the Losi is that it isn't as durable as the other 2. The Losis here break more frequently than the Mugens and Kyoshos. Compare arm size and drive shaft size on a Losi and Mugen/Kyosho to see what I am talking about.