By offset piston pin, you mean the gudgeon pin that connects the piston to the rod? If so, offsetting that doesn't really do anything apart from reducing piston slap when cold AIUI. Useful for 1:1, not so much for our little screamers that rely on pinch.

Offsetting the whole cylinder on the other hand, will probably require a fairly massive re-design of the engine. The intake and exhaust ports will need different timings and probably a different plug as well.