Dont run without low-voltage cut-off. Dont charge with out attending to them and put in charge bag. If storing, make sure you do a storage charge. If storing for a long period, occasionally check on voltages. If cells are out of balance by more than .1 - .2, think of safely disposing it. Dont store in hot location. Store in storage bag and even possibly in vented can.

They are generally safe with proper care but keep in mind they do require proper care.