I used PowerPoles for years (probably 10 years or more). Couple issues with them that led me to switch to XT-60 (though you might switch to something else):

1) The contact area is relatively small compared to connectors commonly used nowadays, which means more resistance and more heat in the connector
2) The heat ends up softening the plastic and thus reducing tension on the contacts because the spring is held by the plastic housing. Reduced pressure means more resistance which means more heat, and so on.
3) One thing I found to dislike about them was they tended to come apart as a result of the weight of the wires in a crash. When I was using them, I made it a point to put some tape on the pair before each run to keep them together. The detent that holds them together just isn't strong enough.
4) They are bigger than a connector needs to be for the amount of current they are rated to carry. (Yeah, this is probably a minor issue.)

Nowadays I don't use Powerpoles for anything any more. Want some to try? Send me a postage paid return envelope and I'll send you a bunch that I took off and replaced with XT-60.