The older 2-in-1 didn't have enough memory to hold programming for multiple versions of ESC, so you could only have one at a time. The newer/current (3-in-1, because of the cell checker) could accomodate all programs at once, therefore, no need to switch anything. This current one should work for all ESC from HW assuming you have the updated software loaded to the programmer.

Did you try it with the 3-in-1?