Kamewadave...

step 1- connect battery (check first all wired correctly)

step 2- turn on radio, then turn on the esc

step 3- check for any codes.. (blinking lights) hopefully none

step 4- confirm all radio trims on the radio are at 0 or 100 (throttle and brake)

step 5- Do the radio calibration (see item 9 on the set-up sheet)
Press and hold the mode button for 3-5 seconds until esc beeps and blinks 4 times... follow the instructions from there to calibrate nuetral, full throttle, brake...

after that you are good to go.
Connect your hotwire and set your esc to what you want. they recommend you try the stock settings to start.

I just set up mine on a Spectrum radio, no issues. I then set up a friends on his Futaba and had to reverse his throttle to get it to calibrate.

hope that helps for what you were asking.