I have an Associated SC10 2wd shortcourse, but recently purchased a TLR22 buggy. I run on a medium sized, clay, indoor track in which the JConcepts gold Barcodes are my preferred choice for both vehicles. My SC10 is faster on the straightaway due to ESC boost options, but the TLR22 buggy is faster and more nimble everywhere else. It's amazing how much quicker and more nimble it feels through the corners and over the jumps. I really like the way it slices through traffic and makes it way through small gaps. To me, the TLR22 just feels like a much more responsive and darty version of the SC10. It just whips around corners and I don't need to worry as much about traction rolling. However, the stress levels increase when I'm out mixing it up with short course trucks and 1:8 scale buggies. In fact, I usually pull it off during those moments and grab one of my short course trucks.
I haven't raced in over 20 years (Kyosho Ultima in 1990 & 1991), but when/if I do return, it'll be the buggy. At my local track, the 2wd buggy guys tend to be much better drivers than the short course guys.