Tooth pitch only affects durability, and adjustability not ratio ! With the same pitch gears ,48p in this example, it is preferable to use smaller, lighter gears : 52t/36t (3.61fdr) is preferable to 65t/45t (3.61fdr) in all cases , whether you run high power motors or not !!! The goal here is to lighten the drivetrain as much as possible, not to make it heavier !!!!!!