Your ESC and spektrum have nothing to do with each other. So if you set the ESC without it then switch to it all you have to do is bind the radio to the RX. If you haven't set the ESC, set the spektrum. Then set up the ESC after.
check the instructions that came with the esc if you dont have them then check out novak website they should have them there, if that fails ask the forum if anyone has the setup instructions for your model esc. just a reminder if you liked the way your car handled before reseting the esc then write the setting down that are on your m8 before you take them back to neutral. this will ensure you have a good starting point in fine tuning hope this helps
what trim??? i suggest you start from scratch. set your radio trims all to neutral, make sure your plugs are in the right receiver slots, and reset your esc. my guess is once you have done that all the problems will go away