Yes you will as the end point will pretty much be different.
if this is a completly new car and your not going to run your old car you can just redo all your set up. shouldn't take to long. Or, if you radio allows it. and your still going to have your old car as a back up or what ever. you could alway set up another model. as some radio allow from 3 model to 20 different setting for different cars. I hope this helps